Manuscript Number : IJSRST218421

Nanotechnology Based Cosmeceuticals

Authors(6) :-Ranajit Nath, Rajarshi Chakraborty, Ratna Roy, Debleena Mukherjee, Srijita Nag, Anirusha Bhattacharya

Nanotechnology manifests the progression within stage of research and development, by increasing the efficacy of the merchandise through delivery of innovative solutions. to beat certain drawbacks associated with the traditional products, application of nanotechnology is escalating within the world of cosmeceuticals. In private care industry, cosmeceuticals are considered the fastest growing segment and thus the use has risen drastically over the years. Nanocosmeceuticals used for skin, hair, nail, and lip care, for conditions like wrinkles, photoaging, hyperpigmentation, dandruff, and hair damage, have inherit widespread use. Novel nanocarriers like nano emulsions, liposomes, microemulsions, niosomes, solid lipid nanoparticles, nanospheres and nanostructured lipid carrier have replaced the usage of conventional delivery system. These novel nanocarriers have advantages of controlled and sustained drug release, enhanced skin penetration, higher stability, high entrapment efficiency and site-specific targeting. However, nanotoxicological researches have indicated concern regarding the impact of increased use of nanoparticles in cosmeceuticals as there are possibilities of nanoparticles to penetrate through skin and cause health hazards. This review on nanotechnology utilized in cosmeceuticals highlights the various novel carriers used for the delivery of cosmeceuticals, marketed formulations, their positive and negative aspects, toxicity, and regulations of nanocosmeceuticals.

Authors and Affiliations

Ranajit Nath
Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata, West Bengal, India
Rajarshi Chakraborty
Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata, West Bengal, India
Ratna Roy
Department of Pharmacology, NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata, West Bengal, India
Debleena Mukherjee
Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata, West Bengal, India
Srijita Nag
Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata, West Bengal, India
Anirusha Bhattacharya
Department of Pharmaceutics, NSHM Knowledge Campus, Kolkata- Group of Institutions, Kolkata, West Bengal, India

Liposomes, Nanocapsule, Solid Lipid Nanoparticles, Nanocrystals

  1. U.S. Food and Drug Administration, “Is it a cosmetic, a drug, or both? (Or is it soap?),” http://www.fda.gov/cosmetics/guidancecomplianceregulatoryinformation/ucm074201.htm.View at: Google Scholar
  2. U.S. Food and Drug Administration, “Cosmetics Q&A: FDA's Authority,” http://www.fda.gov/Cosmetics/ResourcesForYou/Consumers/CosmeticsQA/ucm135709.htm.View at: Google Scholar
  3. M. H. Fulekar, Nanotechnology: Importance and Application, IK International Publishing House, New Delhi, India, 2010.
  4. S. Mukta and F. Adam, “Cosmeceuticals in day-to-day clinical practice,” Journal of Drugs in Dermatology, vol. 9, no. 5, pp. s62–s66, 2010.View at: Google Scholar
  5. “Cosmeceuticals: Products and Global Markets,” http://www.bccresearch.com/market-research/advanced-materials/cosmeceuticals-global-markets-avm099a.html.View at: Google Scholar
  6. F. S. Brandt, A. Cazzaniga, and M. Hann, “Cosmeceuticals: current trends and market analysis,” Seminars in Cutaneous Medicine and Surgery, vol. 30, no. 3, pp. 141–143, 2011.View at: Publisher Site | Google Scholar
  7. RNCOS E-Services Pvt. Ltd., “Global cosmeceuticals market outlook 2016,” http://www.giiresearch.com/report/rnc263147-global-cosmeceuticals-market outlook.html.View at: Google Scholar
  8. GBI Research, “Cosmeceuticals market to 2018—Technological advances and consumer awareness boost commercial potential for innovative and premium-priced products,” http://www.researchandmarkets.com/reports/2393091/cosmeceuticals_market_to_2018_technological.View at: Google Scholar
  9. R. Singh, S. Tiwari, and J. Tawaniya, “Review on nanotechnology with several aspects,” International Journal of Research in Computer Engineering and Electronics, vol. 2, no. 3, pp. 1–8, 2013.View at: Google Scholar
  10. M. N. Padamwar and V. B. Pokharkar, “Development of vitamin loaded topical liposomal formulation using factorial design approach: drug deposition and stability,” International Journal of Pharmaceutics, vol. 320, no. 1-2, pp. 37–44, 2006.View at: Publisher Site | Google Scholar
  11. L. Mu and R. L. Sprando, “Application of nanotechnology in cosmetics,” Pharmaceutical Research, vol. 27, no. 8, pp. 1746–1749, 2010.View at: Publisher Site | Google Scholar
  12. P. Ekambaram, A. A. H. Sathali, and K. Priyanka, “Solid lipid nanoparticles: a review,” Scientific Reviews & Chemical Communications, vol. 2, pp. 80–102, 2012.View at: Google Scholar
  13. D. Bei, J. Meng, and B.-B. C. Youan, “Engineering nanomedicines for improved melanoma therapy: progress and promises,” Nanomedicine, vol. 5, no. 9, pp. 1385–1399, 2010.View at: Publisher Site | Google Scholar
  14. A. D. Bangham, “Physical structure and behavior of lipids and lipid enzymes,” Advances in Lipid Research, vol. 64, pp. 65–104, 1963.View at: Google Scholar
  15. M. Mezei and V. Gulasekharam, “Liposomes - a selective drug delivery system for the topical route of administration. I. Lotion dosage form,” Life Sciences, vol. 26, no. 18, pp. 1473–1477, 1980.View at: Publisher Site | Google Scholar
  16. I. P. Kaur and R. Agrawal, “Nanotechnology: a new paradigm in cosmeceuticals,” Recent Patents on Drug Delivery & Formulation, vol. 1, no. 2, pp. 171–182, 2007.View at: Google Scholar
  17. D. D. Lasic, “Novel applications of liposomes,” Trends in Biotechnology, vol. 16, no. 7, pp. 307–321, 1998.View at: Publisher Site | Google Scholar
  18. C. C. Müller-Goymann, “Physicochemical characterization of colloidal drug delivery systems such as reverse micelles, vesicles, liquid crystals and nanoparticles for topical administration,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 58, no. 2, pp. 343–356, 2004.View at: Publisher Site | Google Scholar
  19. F. S. Poletto, R. C. R. Beck, S. S. Guterres, and A. R. Pohlmann, “Polymeric nanocapsule: concepts and applications,” in Nanocosmetics and Nanomedicines: New Approaches for Skin Care, R. Beck, S. Guterres, and A. Pohlmann, Eds., pp. 47–51, Springer, Berlin, Germany, 2011.View at: Google Scholar
  20. P. Kothamasu, H. Kanumur, N. Ravur et al., “Nanocapsules: the weapons for novel drug delivery systems,” BioImpacts, vol. 2, no. 2, pp. 71–81, 2012.View at: Google Scholar
  21. J. Pardeike, A. Hommoss, and R. H. Müller, “Lipid nanoparticles (SLN, NLC) in cosmetic and pharmaceutical dermal products,” International Journal of Pharmaceutics, vol. 366, no. 1-2, pp. 170–184, 2009.View at: Publisher Site | Google Scholar
  22. R. H. Müller, R. D. Petersen, A. Hommoss, and J. Pardeike, “Nanostructured lipid carriers (NLC) in cosmetic dermal products,” Advanced Drug Delivery Reviews, vol. 59, no. 6, pp. 522–530, 2007.View at: Publisher Site | Google Scholar
  23. S. A. Wissing, K. Mader, and R. H. Muller, “Solid lipid nanopartices (SLN) as a novel carrier system offering prolonged release of the perfume Allure (Chanel),” in Proceedings of the International Symposium on Controlled Release of Bioactive Materials, vol. 27, pp. 311–312, Paris, France, 2000.View at: Google Scholar
  24. Z. Mei, Q. Wu, S. Hu, X. Li, and X. Yang, “Triptolide loaded solid lipid nanoparticle hydrogel for topical application,” Drug Development and Industrial Pharmacy, vol. 31, no. 2, pp. 161–168, 2005.View at: Publisher Site | Google Scholar
  25. E. B. Souto and R. H. Müller, “Cosmetic features and applications of lipid nanoparticles (SLN, NLC),” International Journal of Cosmetic Science, vol. 30, no. 3, pp. 157–165, 2008.View at: Publisher Site | Google Scholar
  26. C. M. Keck and R. H. Müller, “Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation,” European Journal of Pharmaceutics and Biopharmaceutics, vol. 62, no. 1, pp. 3–16, 2006.View at: Publisher Site | Google Scholar
  27. J. Sakamoto, A. Annapragada, P. Decuzzi, and M. Ferrari, “Antibiological barrier nanovector technology for cancer applications,” Expert Opinion on Drug Delivery, vol. 4, no. 4, pp. 359–369, 2007.View at: Publisher Site | Google Scholar
  28. R. Petersen, “Nanocrystals for use in topical cosmetic formulations and method of production thereof,” US Patent US 20100047297A1. February 2010.View at: Google Scholar
  29. “Dendrimers & Dendrons: Facets of Pharmaceutical Nanotechnology,” Drug-Dev Newsletter, http://www.kellerfoundation.com/ME2/dirmod.asp?sid=4306B1E9C3CC4E07A4D64E23FBDB232C&nm= Back+Issues&type=Publishing&mod=Publications%3A%3AArticle&mid=8F3A7027421841978F18BE895F 87F791&tier=4&id=9B9BA1DAA5BE455A85A81D97382FE885.View at: Google Scholar
  30. F. Tournihac and P. Simon, “Cosmetic or dermatological topical compositions comprising dendritic polyesters,” U.S. Patent 6,287,552, September 2001.View at: Google Scholar
  31. H. Furukawa and T. Limura, “Copolymer having carbosiloxane dendrimer structure, and composition and cosmetic containing the same,” U.S. Patent 20120263662A1, October 2012.View at: Google Scholar
  32. Y. Lin and L. Yan, “Broad spectrum anti-bactericidal ointment nano.,” CN Patent. CN 1480045 A. March 2004.View at: Google Scholar
  33. “First synthesis of gold nanoparticles inside human hair for dyeing and much more,” http://www.nanowerk.com/news2/newsid=28260.php.View at: Google Scholar
  34. S. Hyde, A. Andersson, K. Larsson et al., The Language of Shape, Elsevier, New York, NY, USA, 1st edition, 1997.
  35. S. C. Kimmes and C. Feltin, “Cosmetic composition comprising an oil and a polymer both bearing a hydrogen-bond-generating joining group, and cosmetic treatment process,” European Patent 2575751A1, April 2013.View at: Google Scholar
  36. A. Ribier and B. Biatry, “Cosmetic or dermatologic oil/water dispersion stabilized with cubic gel particles and method of preparation,” European Patent 0711540B1, May 2000.View at: Google Scholar
  37. H. Albrecht and J. Schreiber, “Hair care products with disperse liquid crystals exhibiting the cubic phases,” W.O. Patent 2002041850A1, May 2002.View at: Google Scholar
  38. J. T. Simonnet, O. Sonneville, and S. Legret, “Nanoemulsion based on phosphoric acid fatty acid esters and its uses in the cosmetics, dermatological, pharmaceutical, and/or ophthalmological fields,” U.S. Patent 6274150 B1, August 2001.View at: Google Scholar
  39. S. Anisha, S. P. Kumar, G. V. Kumar, and G. Garima, “Approaches used for penetration enhancement in transdermal drug delivery system,” International Journal of Pharmaceutical Sciences, vol. 2, no. 3, pp. 708–716, 2010.View at: Google Scholar
  40. A. Sankhyan and P. Pawar, “Recent trends in noisome as vesicular drug delivery system,” Journal of Applied Pharmaceutical Science, vol. 2, pp. 20–32, 2012.View at: Google Scholar
  41. M. Lens, “Use of fullerenes in cosmetics,” Recent Patents on Biotechnology, vol. 3, no. 2, pp. 118–123, 2009.View at: Publisher Site | Google Scholar
  42. H. W. Kroto, J. R. Heath, S. C. O'Brien, R. F. Curl, and R. E. Smalley, “C60: Buckminsterfullerene,” Nature, vol. 318, no. 6042, pp. 162–163, 1985.View at: Publisher Site | Google Scholar
  43. C. Cusan, T. Da Ros, G. Spalluto et al., “A new multi-charged C60 derivative: synthesis and biological properties,” European Journal of Organic Chemistry, no. 17, pp. 2928–2934, 2002.View at: Google Scholar
  44. M. D. Carmen, V. Pereda, A. Polezel et al., “Sericin cationic nanoparticles for application in products for hair and dyed hair,” U.S. Patent 20120164196, June 2012.View at: Google Scholar
  45. T. G. Smijs and S. Pavel, “Titanium dioxide and zinc oxide nanoparticles in sunscreens: focus on their safety and effectiveness,” Nanotechnology, Science and Applications, vol. 4, no. 1, pp. 95–112, 2011.View at: Google Scholar
  46. T. Faunce, “Exploring the safety of nanoparticles in Australian Sunscreens,” International Journal of Biomedical Nanoscience and Nanotechnology, vol. 1, pp. 87–94, 2010.View at: Google Scholar
  47. L'Oreal Paris, http://www.lorealparisusa.com/en/Products/Skin Care/Moisturizers/RevitaLift-Anti-Wrinkle-Firming-Day-Cream-SPF-18.aspx.
  48. Z. D. Draelos, “Retinoids in cosmetics,” Cosmetic Dermatology, vol. 18, no. 1, pp. 3–5, 2005.View at: Google Scholar
  49. C. M. Choi and D. S. Berson, “Cosmeceuticals,” Seminars in Cutaneous Medicine and Surgery, vol. 25, no. 3, pp. 163–168, 2006.View at: Publisher Site | Google Scholar
  50. “The project on emerging nanotechnologies,” http://www.nanotechproject.org/inventories/consumer/browse/products/5043/.View at: Google Scholar
  51. D. Ereno, “Well-grounded Beauty,” http://revistapesquisa.fapesp.br/en/2008/04/01/wellgrounded-beauty/.View at: Google Scholar
  52. K. Ertel, “Personal cleansing products: properties and use,” in Cosmetic Formulation of Skin Care Products, Z. D. Draelos and L. A. Thaman, Eds., pp. 32–36, Taylor & Francis, New York, NY, USA, 2006.View at: Google Scholar
  53. “Nanocyclic cleanser pink,” http://www.nanocyclic.com/ProductDetails.asp?ProductCode=CY-40P.View at: Google Scholar
  54. T. H. Ha, J. Y. Jeong, B. T. Y. H. Jung, and J. K. Kim, “Cosmetic pigment composition containing gold or silver nano-particles,” European Patent 1909745A1, April 2008.View at: Google Scholar
  55. P. J. L. Viladot, G. R. Delgado, and B. A. Fernandez, “Lipid nanoparticle capsules.,” European Patent 2549977A2, January 2013.View at: Google Scholar
  56. S. W. Amato, A. Farer, W. M. Hoyte, M. Pavlovsky et al., “Coatings for mammalian nails that include nanosized particles,” U.S. Patent 2007/002207, August 2007.View at: Google Scholar
  57. NanoLabs, http://nanolabs.us/press-releases/green-chemistry-and-new-thinking-at-playas-nano-labs-ctle-receives-provisional-patent-for-unique-nanotech-nail-polish/.
  58. G. Oberdörster, E. Oberdörster, and J. Oberdörster, “Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles,” Environmental Health Perspectives, vol. 113, no. 7, pp. 823–839, 2005.View at: Publisher Site | Google Scholar
  59. C. S. Yah, G. Simate, and S. E. Iyuke, “Nanoparticles toxicity and their routes of exposures,” Pakistan Journal of Pharmaceutical Sciences, vol. 25, no. 2, pp. 477–491, 2012.View at: Google Scholar
  60. J. A. B. Paul and P. F. S. Roel, “Toxicological characterization of engineered nanoparticles,” in Nanoparticle Technology for Drug Delivery, R. B. Gupta and U. B. Kompella, Eds., pp. 161–170, Taylor & Francis, New York, NY, USA, 2006.View at: Google Scholar
  61. S. Raj, S. Jose, U. S. Sumod, and M. Sabitha, “Nanotechnology in cosmetics: opportunities and challenges,” Journal of Pharmacy and Bioallied Sciences, vol. 4, no. 3, pp. 186–193, 2012.View at: Google Scholar
  62. C. Buzea, I. I. P. Blandino, and K. Robbie, “Nanomaterials and nanoparticles: sources and toxicity,” Biointerphases, vol. 4, pp. MR17–MR172, 2007.View at: Google Scholar
  63. H. A. E. Benson, “Transdermal drug delivery: penetration enhancement techniques,” Current Drug Delivery, vol. 2, no. 1, pp. 23–33, 2005.View at: Publisher Site | Google Scholar
  64. M.-A. Bolzinger, S. Briançon, J. Pelletier, and Y. Chevalier, “Penetration of drugs through skin, a complex rate-controlling membrane,” Current Opinion in Colloid and Interface Science, vol. 17, no. 3, pp. 156–165, 2012.View at: Publisher Site | Google Scholar
  65. G. Cevc and U. Vierl, “Nanotechnology and the transdermal route. A state of the art review and critical appraisal,” Journal of Controlled Release, vol. 141, no. 3, pp. 277–299, 2010.View at: Publisher Site | Google Scholar
  66. R. Toll, U. Jacobi, H. Richter, J. Lademann, H. Schaefer, and U. Blume-Peytavi, “Penetration profile of microspheres in follicular targeting of terminal hair follicles,” Journal of Investigative Dermatology, vol. 123, no. 1, pp. 168–176, 2004.View at: Publisher Site | Google Scholar
  67. S. J. Christopher, L. Campbell, L. R. Contreras-Rojas et al., “Objective assessment of nanoparticle disposition in mammalian skin after topical exposure,” Journal of Controlled Release, vol. 162, no. 1, pp. 201–207, 2012.View at: Google Scholar
  68. B. Gulson, M. Mccall, M. Korsch et al., “Small amounts of zinc from zinc oxide particles in sunscreens applied outdoors are absorbed through human skin,” Toxicological Sciences, vol. 118, no. 1, pp. 140–149, 2010.View at: Publisher Site | Google Scholar
  69. B. Gulson, M. McCall, L. Gomez, M. Korsch et al., “Dermal absorption of ZnO particles from sunscreens applied to humans at the beach,” in International Conference on Nanoscience and Nanotechnology, Sydney, Australia, February 2010.View at: Google Scholar
  70. M. Senzui, T. Tamura, K. Miura, Y. Ikarashi, Y. Watanabe, and M. Fujii, “Study on penetration of titanium dioxide (TiO2) nanoparticles into intact and damaged skin in vitro,” Journal of Toxicological Sciences, vol. 35, no. 1, pp. 107–113, 2010.View at: Publisher Site | Google Scholar
  71. T. Butz, “Dermal penetration of nanoparticles: what we know and what we don't. Cosmetic. Science Conference Proceedings, Munich,” SÖFW Journal, vol. 135, no. 4, pp. 8–10, 2009.View at: Google Scholar
  72. P. Filipe, J. N. Silva, R. Silva et al., “Stratum corneum is an effective barrier to TiO2 and ZnO nanoparticle percutaneous absorption,” Skin Pharmacology and Physiology, vol. 22, no. 5, pp. 266–275, 2009.View at: Publisher Site | Google Scholar
  73. A. Mavon, C. Miquel, O. Lejeune, B. Payre, and P. Moretto, “In vitro percutaneous absorption and in vivo stratum corneum distribution of an organic and a mineral sunscreen,” Skin Pharmacology and Physiology, vol. 20, no. 1, pp. 10–20, 2006.View at: Publisher Site | Google Scholar
  74. F. Pflücker, V. Wendel, H. Hohenberg et al., “The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide,” Skin Pharmacology and Applied Skin Physiology, vol. 14, no. 1, pp. 92–97, 2001.View at: Publisher Site | Google Scholar
  75. F. Menzel, T. Reinert, J. Vogt, and T. Butz, “Investigations of percutaneous uptake of ultrafine TiO2 particles at the high energy ion nanoprobe LIPSION,” Nuclear Instruments and Methods in Physics Research, Section B: Beam Interactions with Materials and Atoms, vol. 219-220, no. 1-4, pp. 82–86, 2004.View at: Publisher Site | Google Scholar
  76. J. Lademann, H.-J. Weigmann, C. Rickmeyer et al., “Penetration of titanium dioxide microparticles in a sunscreen formulation into the horny layer and the follicular orifice,” Skin Pharmacology and Applied Skin Physiology, vol. 12, no. 5, pp. 247–256, 1999.View at: Publisher Site | Google Scholar
  77. A. S. Dussert and E. Gooris, “Characterisation of the mineral content of a physical sunscreen emulsion and its distribution onto human stratum corneum,” International Journal of Cosmetic Science, vol. 19, pp. 119–129, 1997.View at: Google Scholar
  78. K. Takeda, K.-I. Suzuki, A. Ishihara et al., “Nanoparticles transferred from pregnant mice to their offspring can damage the genital and cranial nerve systems,” Journal of Health Science, vol. 55, no. 1, pp. 95–102, 2009.View at: Publisher Site | Google Scholar
  79. R. Dunford, A. Salinaro, L. Cai et al., “Chemical oxidation and DNA damage catalysed by inorganic sunscreen ingredients,” FEBS Letters, vol. 418, pp. 87–90, 1997.View at: Google Scholar
  80. S. Arora, J. M. Rajwade, and K. M. Paknikar, “Nanotoxicology and in vitro studies: the need of the hour,” Toxicology and Applied Pharmacology, vol. 258, no. 2, pp. 151–165, 2012.View at: Publisher Site | Google Scholar
  81. W. H. De Jong and P. J. A. Borm, “Drug delivery and nanoparticles: applications and hazards,” International Journal of Nanomedicine, vol. 3, no. 2, pp. 133–149, 2008.View at: Google Scholar
  82. V. K. M. Poon and A. Burd, “In vitro cytotoxity of silver: implication for clinical wound care,” Burns, vol. 30, no. 2, pp. 140–147, 2004.View at: Publisher Site | Google Scholar
  83. U.S. Food and Drug Administration, “Import Alert 66-38,” http://www.accessdata.fda.gov/cms_ia/importalert_188.html.View at: Google Scholar
  84. “Nanomaterials and the EU Cosmetics Regulation: Implications for Your Company,” http://www.gcimagazine.com/business/management/regulation/143553126.html?pa.View at: Google Scholar

Publication Details

Published in : Volume 8 | Issue 4 | July-August 2021
Date of Publication : 2021-08-30
License:  This work is licensed under a Creative Commons Attribution 4.0 International License.
Page(s) : 94-106
Manuscript Number : IJSRST218421
Publisher : Technoscience Academy

Print ISSN : 2395-6011, Online ISSN : 2395-602X

Cite This Article :

Ranajit Nath, Rajarshi Chakraborty, Ratna Roy, Debleena Mukherjee, Srijita Nag, Anirusha Bhattacharya, " Nanotechnology Based Cosmeceuticals", International Journal of Scientific Research in Science and Technology(IJSRST), Print ISSN : 2395-6011, Online ISSN : 2395-602X, Volume 8, Issue 4, pp.94-106, July-August-2021. Available at doi : https://doi.org/10.32628/IJSRST218421    
Journal URL : https://ijsrst.com/IJSRST218421
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